The Assault On Medicaid Could Endanger Millions Of Americans

Since 1965, Medicaid has been the forgotten child of the federal entitlement programs, even though it costs less and covers more people than Medicare. And in 2010, the Affordable Care Act expanded the program to give millions of more people coverage. But Republicans in Congress, and Trump, are on the precipice of radically altering the program in a way that could cost tens of millions people their health insurance. http://jeremysilksmith.com/the-assault-on-medicaid-could-endanger-millions-of-americans

Cre/lox generation of a novel whole-body Kiss1r KO mouse line recapitulates a hypogonadal, obese, and metabolically-impaired phenotype.

Kisspeptin and its receptor, Kiss1r, act centrally to stimulate reproduction. Recent evidence indicates that kisspeptin is also important for body weight and metabolism, as whole-body Kiss1r KO mice, developed with gene trap technology, display obesity and reduced metabolism. Kiss1r is expressed in brain and multiple peripheral tissues, but it is unknown which is responsible for the metabolic phenotype. Here, we sought to confirm that 1) the metabolic phenotype of the gene trap Kiss1r KOs is due to disruption of kisspeptin signaling and not off-target effects of viral mutagenesis, and 2) the Kiss1r flox line is suitable for creating conditional KOs to study the metabolic phenotype. We used Cre/lox technology (Zp3-Cre/Kiss1r flox) to develop a new global Kiss1r KO ("Kiss1r gKO") to compare with the original gene trap KO phenotype. We confirmed that deleting exon 2 of Kiss1r from the entire body induces hypogonadism in both sexes. Moreover, global deletion of Kiss1r induced obesity in females, but not males, along with increased adiposity and impaired glucose tolerance, similar to the gene trap Kiss1r KOs. Likewise, Kiss1r gKO females had decreased VO2 and VCO2, likely underlying their obesity. These findings support that our previous results in gene trap Kiss1r KOs are due to disrupted kisspeptin signaling, and further highlight a role for Kiss1r signaling in energy expenditure and metabolism besides controlling reproduction. Moreover, given Kiss1r expression in multiple cell-types, our findings indicate that the Kiss1r flox line is viable for future investigations to isolate specific target cells of kisspeptin's metabolic effects

An analysis of the Patents Granted to the University of Arkansas, Fayetteville, 2010-2019

This report provides an analysis of the patents were granted for ten years (2010-2019) where at least one of the inventors is affiliated with a department or college from the University of Arkansas in Fayetteville. It identifies the number of patents with inventors from the various departments; the number of unique inventors in each department; and the college affiliations of the inventors; their inter- and extra-collegiate collaborators from campus and their off-campus campus collaborators

The GHOSTS survey. II. The diversity of Halo Color and Metallicity Profiles of Massive Disk Galaxies

We study the stellar halo color properties of six nearby massive highly inclined disk galaxies using Hubble Space Telescope Advanced Camera for Surveys and Wide Field Camera 3 observations in both F606W and F814W filters from the GHOSTS survey. The observed fields, placed both along the minor and major axis of each galaxy, probe the stellar outskirts out to projected distances of ~ 50-70 kpc from their galactic centre along the minor axis. The 50% completeness levels of the color magnitude diagrams are typically at two mag below the tip of the red giant branch. We find that all galaxies have extended stellar halos out to ~ 50 kpc and two out to ~ 70 kpc. We determined the halo color distribution and color profile for each galaxy using the median colors of stars in the RGB. Within each galaxy we find variations in the median colors as a function of radius which likely indicates population variations, reflecting that their outskirts were built from several small accreted objects. We find that half of the galaxies (NGC 0891, NGC 4565, and NGC 7814) present a clear negative color gradient, reflecting a declining metallicity in their halos; the other have no significant color or population gradient. In addition, notwithstanding the modest sample size of galaxies, there is no strong correlation between their halo color/metallicity or gradient with galaxy's properties such as rotational velocity or stellar mass. The diversity in halo color profiles observed in the GHOSTS galaxies qualitatively supports the predicted galaxy-to-galaxy scatter in halo stellar properties; a consequence of the stochasticity inherent in the assembling history of galaxies.Comment: Accepted by MNRAS, 31 pages, 18 figures. Appendix added and some editions to match accepted version. Conclusions unchange

Cis/trans energetics in epoxide, thiirane, aziridine and phosphirane containing cyclopentanols: Effects of intramolecular OH···O,S,N and P contacts

c 2019 by the authors A recent computational analysis of the stabilizing intramolecular OH···O contact in 1,2-dialkyl-2,3-epoxycyclopentanol diastereomers has been extended to thiiriane, aziridine and phosphirane analogues. Density functional theory (DFT), second-order Møller-Plesset perturbation theory (MP2) and CCSD(T) coupled-cluster computations with simple methyl and ethyl substituents indicate that electronic energies of the cis isomers are lowered by roughly 3 to 4 kcal mol−1 when the OH group of these cyclopentanol systems forms an intramolecular contact with the O, S, N or P atom on the adjacent carbon. The results also suggest that S and P can participate in these stabilizing intramolecular interactions as effectively as O and N in constrained molecular environments. The stabilizing intramolecular OH···O, OH···S, OH···N and OH···P contacts also increase the covalent OH bond length and significantly decrease the OH stretching vibrational frequency in every system with shifts typically on the order of −41 cm−

Diverse Stellar Haloes in Nearby Milky Way-Mass Disc Galaxies

We have examined the resolved stellar populations at large galactocentric distances along the minor axis (from 10 kpc up to between 40 and 75 kpc), with limited major axis coverage, of six nearby highly-inclined Milky Way-mass disc galaxies using HST data from the GHOSTS survey. We select red giant branch stars to derive stellar halo density profiles. The projected minor axis density profiles can be approximated by power laws with projected slopes of between $-2$ and $-3.7$ and a diversity of stellar halo masses of $1-6\times 10^{9}M_{\odot}$, or $2-14\%$ of the total galaxy stellar masses. The typical intrinsic scatter around a smooth power law fit is $0.05-0.1$ dex owing to substructure. By comparing the minor and major axis profiles, we infer projected axis ratios $c/a$ at $\sim 25$ kpc between $0.4-0.75$. The GHOSTS stellar haloes are diverse, lying between the extremes charted out by the (rather atypical) haloes of the Milky Way and M31. We find a strong correlation between the stellar halo metallicities and the stellar halo masses. We compare our results with cosmological models, finding good agreement between our observations and accretion-only models where the stellar haloes are formed by the disruption of dwarf satellites. In particular, the strong observed correlation between stellar halo metallicity and mass is naturally reproduced. Low-resolution hydrodynamical models have unrealistically high stellar halo masses. Current high-resolution hydrodynamical models appear to predict stellar halo masses somewhat higher than observed but with reasonable metallicities, metallicity gradients and density profiles.Comment: 26 pages, 17 figures. Accepted for publication in MNRA